Start Aromatase Steroid-Biosynthese

Steroid-Biosynthese

David Richfield (User:Slashme) and Mikael Häggström. Derived from previous version by Hoffmeier and Settersr. In external use, this diagram may be cited as: Häggström M, Richfield D (2014). „Diagram of the pathways of human steroidogenesis“. Wikiversity Journal of Medicine 1 (1). DOI:10.15347/wjm/2014.005. ISSN 20018762. – Self-made using bkchem and inkscape

Enzymes, their cellular location, substrates and products in human steroidogenesis. Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids. White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see Wikipedia:structural formula. HSD: Hydroxysteroid dehydrogenase References: Walter F. Boron, Emile L. Boulpaep (2003) Medical Physiology: A Cellular And Molecular Approach, Elsevier/Saunders, S. page 1,300 ISBN: 1-4160-2328-3. For the absence of conversion of corticosterone to cortisol: Steroid hormone biosynthesis – Reference pathway (KO) from Kyoto University Bioinformatics Center. 1/11/13 There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase. See also: Wikiversity:Diagram of the pathways of human steroidogenesis
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